C14-4

• UNSPSC Description:

  C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity[1].

• Target Antigen:

  Liposome

• Type:

  Oligonucleotides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/c14-4.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|Ethanol : 100 mg/mL (ultrasonic)

• Smiles:

  OC(CCCCCCCCCCCC)CN(CCN1CCN(CC1)CCOCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)CCOCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O

• Molecular Weight:

  1365.30

• References & Citations:

  [1]Billingsley MM, et al. Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering. Nano Lett. 2020 Mar 11;20(3):1578-1589.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  2639634-80-1