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Sabizabulin

CAT: 0804-HY-120599-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120599-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VERU-111 (ABI-231) is a potent and orally active α and β tubulin inhibitor, which displays strong antiproliferative activity, with an average IC50 of 5.2 nM against panels of melanoma and prostate cancer cell lines. VERU-111 (ABI-231) suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7, and has potential for the treatment of prostate cancer[1][2][3].
CAS Number
1332881-26-1
Product Name Alternative
VERU-111; ABI-231
UNSPSC
12352005
Target
Apoptosis; HPV; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/veru-111.html
Purity
99.00
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(C1=CNC(C2=CNC3=C2C=CC=C3)=N1)C4=CC(OC)=C(OC)C(OC)=C4
Molecular Formula
C21H19N3O4
Molecular Weight
377.39
References & Citations
[1]Wang Q, et al. Structure-Guided Design, Synthesis, and Biological Evaluation of (2- (1H-Indol-3-yl) -1H-imidazol-4-yl) (3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin. J Med Chem. 2019 Jul 12.|[2]Qinghui Wang, et al. Discovery of ABI-231 analogs targeting the colchicine site in tubulin for advanced melanoma. Cancer Research 76 (14 Supplement) :4848-4848.|[3]Vivek Kashyap, et al. ABI-231: A novel small molecule suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting Human papilloma virus (HPV) E6 and E7. Cancer Research 78 (13 Supplement) :679-679.|[4]Kashyap VK, et al. Therapeutic efficacy of a novel βIII/βIV-tubulin inhibitor (VERU-111) in pancreatic cancer. J Exp Clin Cancer Res. 2019 Jan 23;38 (1) :29.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
GTR19202940-01Sabizabulin
A18743-100Sabizabulin (VERU-111) 100mg
A18743-25Sabizabulin (VERU-111) 25mg
A18743-1Sabizabulin (VERU-111) 1mg
A18743-500Sabizabulin (VERU-111) 500mg
A18743-2Sabizabulin (VERU-111) 2mg

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