Monoclonal Anti-Human p-tau181 Antibody, Mouse IgG2a (8D8C10) (MALS verified)

Monoclonal Anti-Human p-tau181 Antibody, Mouse IgG2a (8D8C10) (MALS verified)

• Background: Tau, the microtubule‐associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under physiological conditions, tau regulates the assembly and maintenance of the structural stability of microtubules. In the diseased brain, however, tau becomes abnormally hyperphosphorylated, which ultimately causes the microtubules to disassemble, and the free tau molecules aggregate into paired helical filaments.
• Description: Tau, the microtubule‐associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under physiological conditions, tau regulates the assembly and maintenance of the structural stability of microtubules. In the diseased brain, however, tau becomes abnormally hyperphosphorylated, which ultimately causes the microtubules to disassemble, and the free tau molecules aggregate into paired helical filaments.
• CAS Number: 9007-83-4
• Host: HEK 293
• Origin Species: Mouse
• Target: p-tau181
• Conjugation: Unconjugated
• Tag: Mouse IgG2a | Mouse Kappa
• Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower._x000D_Please avoid repeated freeze-thaw cycles.
• Purity: 95%
• Bioactivity: Immobilized Recombinant Human P-Tau181, His tag at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human p-tau181 Antibody, Mouse IgG2a (8D8C10) (Cat. No. PT1-MY2073) with a linear range of 0.3-5 ng/mL (QC tested).
• Format: Powder
• Buffer: PBS, pH7.4
• Additives: Trehalose
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C