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Inflachromene

CAT: 0804-HY-113772-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113772-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Inflachromene, a microglial inhibitor, binds to HMGB1 and HMGB2 and exerts anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage. Inflachromene can be used for the research of neuroinflammatory disorders[1][2].
CAS Number
908568-01-4
Product Name Alternative
(-)-PX-102 (trans isomer); (-)-PX-104
UNSPSC
12352005
Target
ERK; JNK; NF-κB; p38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/inflachromene.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=CC=C2)C(N3CC=C(C(C)(C)OC4=CC(O)=CC=C45)C5N31)=O
Molecular Formula
C21H19N3O4
Molecular Weight
377.39
References & Citations
[1]Lee HH, et, al. A validated UPLC-MS/MS method for pharmacokinetic study of inflachromene, a novel microglia inhibitor. J Pharm Biomed Anal. 2019 Mar 20; 166: 183-188.|[2]Lee S, et, al. A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nat Chem Biol. 2014 Dec; 10 (12) : 1055-60.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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