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KPH2f

CAT: 0804-HY-144305-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144305-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KPH2f is a safe, orally active, and effective dual URAT1/GLUT9 inhibitor with IC50s of 0.24 μM and 9.37 μM for URAT1 and GLUT9, respectively. KPH2f shows little effects on OAT1 and ABCG2 (IC50=32.14 and 26.74 μM) [1].
CAS Number
2760615-09-4
UNSPSC
12352005
Target
GLUT; URAT1
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/kph2f.html
Purity
99.22
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
N#CC1=C2C=CC=CC2=C(C=C1)NC3=C(C=CN=C3)SCC4=CC=CC=C4C(O[Na])=O
Molecular Formula
C24H16N3NaO2S
Molecular Weight
433.46
References & Citations
[1]Zhao Z, et al. Discovery of novel verinurad analogs as dual inhibitors of URAT1 and GLUT9 with improved Druggability for the treatment of hyperuricemia. Eur J Med Chem. 2022;229:114092.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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