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Galiximab

CAT: 0804-HY-P99293-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99293-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Galiximab (IDEC-114) is a primatized monoclonal IgG1 antibody targeting CD80. Galiximab variable regions are primatized, and the constant regions are humanized. Galiximab induces antibody-dependent cellular cytotoxicity by blocking CD80-CD28 binding. Galiximab has antitumor activity and can induce apoptosis in tumor cells. Galiximab can be used in the research of relapsed Hodgkin lymphoma and solid tumors[1][2].
CAS Number
357613-77-5
Product Name Alternative
IDEC 114; Anti-Human CD80 Recombinant Antibody
UNSPSC
12352203
Target
Apoptosis; CD28
Type
Inhibitory Antibodies
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/galiximab.html
Purity
99.23
Solubility
10 mM in DMSO
Smiles
[Galiximab]
Molecular Weight
(145.24 kDa)
References & Citations
[1]Smith SM, et, al. The anti-CD80 primatized monoclonal antibody, galiximab, is well-tolerated but has limited activity in relapsed Hodgkin lymphoma: Cancer and Leukemia Group B 50602 (Alliance) . Leuk Lymphoma. 2013 Jul;54 (7) :1405-10.|[2]Hariharan K, et al. Galiximab (anti-CD80) -induced growth inhibition and prolongation of survival in vivo of B-NHL tumor xenografts and potentiation by the combination with fludarabine. Int J Oncol. 2013 Aug;43 (2) :670-6.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3

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