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Linerixibat

CAT: 0804-HY-16643-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16643-01Size:1 mg
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Description
Linerixibat (GSK2330672) is a highly potent, nonabsorbable and orally active apical sodium-dependent bile acid transporter (ASBT) inhibitor with an IC50 of 42 nM human ASBT. Linerixibat can be used as lipid-lowering agent. Linerixibat has the potential for type 2 diabetes and Primary Biliary Cholangitis treatment[1][2][3].
CAS Number
1345982-69-5
Product Name Alternative
GSK2330672
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H401, H411
Target
Apical Sodium-Dependent Bile Acid Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/GSK2330672.html
Purity
99.88
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)CC(NCC1=C(OC)C=C(C2=C1)[C@@H](C3=CC=CC=C3)N[C@](CC)(CCCC)CS2(=O)=O)CC(O)=O
Molecular Formula
C28H38N2O7S
Molecular Weight
546.68
Precautions
H302, H315, H319, H335, H401, H411
References & Citations
[1]Wu Y, et al. Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem. 2013 Jun 27;56 (12) :5094-114.|[2]Linerixibat (GSK2330672) granted Orphan Status. September 24, 2019.|[3]Wang Y, et al. HNF4α Regulates CSAD to Couple Hepatic Taurine Production to Bile Acid Synthesis in Mice. Gene Expr. 2018 Aug 22;18 (3) :187-196.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
C09404-5mgLinerixibat
A13875-1Linerixibat (GSK2330672) 1mg
A13875-2Linerixibat (GSK2330672) 2mg
A13875-100Linerixibat (GSK2330672) 100mg
A13875-50Linerixibat (GSK2330672) 50mg
A13875-25Linerixibat (GSK2330672) 25mg
A13875-10Linerixibat (GSK2330672) 10mg
A13875-5Linerixibat (GSK2330672) 5mg
A13875-10mM-DLinerixibat (GSK2330672) 10mM * 1mL in DMSO

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