DB04760

CAT: 0804-HY-125166-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-125166-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM[1]. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity[2].

CAS Number

544678-85-5

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/db04760.html

Purity

99.18

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=C(C=C(C=C1)CNC(C2=CC(C(NCC3=CC=C(C(C)=C3)F)=O)=NC=N2)=O)C

Molecular Formula

C22H20F2N4O2

Molecular Weight

410.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Engel CK, et al. Structural basis for the highly selective inhibition of MMP-13. Chem Biol. 2005 Feb;12 (2) :181-9.|[2]Thomas S. Lisse, et al. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A. 2016 Apr 12; 113 (15) : E2189–E2198.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MMP-13

Alternative Products

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M33333-01	DB04760
A18548-500	DB04760 500mg
A18548-10	DB04760 10mg
A18548-100	DB04760 100mg
A18548-50	DB04760 50mg
A18548-25	DB04760 25mg
A18548-5	DB04760 5mg
A18548-1	DB04760 1mg
MBS5755984	DB04760 analog 1
A18548-10mM-D	DB04760 10mM * 1mL in DMSO

DB04760

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