Raloxifene

• Description :

  Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM) . Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[1].

• Product Name Alternative :

  Keoxifene; LY156758 (free base) ; LY139481

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H332

• Target :

  Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/raloxifene.html

• Purity :

  99.62

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4

• Molecular Formula :

  C28H27NO4S

• Molecular Weight :

  473.58

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Khovidhunkit W, et al. Clinical effects of raloxifene hydrochloride in women. Ann Intern Med. 1999;130 (5) :431-439.|[2]Xu H, et al. Effect of caffeine on ovariectomy-induced osteoporosis in rats. Biomed Pharmacother. 2019;112:108650.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  Estrogen receptor

• Citation 01 :

  ACS Environ Au. 2025 Aug 8.|ACS Omega. 2023 Jun 14;8 (25) :22603-22612.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Biomed Pharmacother. 2025 Jan:182:117756.|bioRxiv. 2025 Sep 4.|Exp Mol Med. 2025 Sep;57 (9) :1978-1995.|J Pharm Biomed Anal. 2021 Feb 20:195:113870.|Mol Neurobiol. 2025 Mar;62 (3) :3934-3955.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Eberhard Karls Universität Tübingen. 2021 Aug.|Free Radic Biol Med. 2017 Jul:108:404-417.|Int Immunopharmacol. 2024 Nov 6;143 (Pt 3) :113542.|Med Sci Monit. 2019 Apr 29:25:3146-3153.|Oxid Med Cell Longev. 2021 Mar 20;2021:6699054.|PLoS Negl Trop Dis. 2019 Aug 20;13 (8) :e0007681. |Res Sq. 2020 Dec 31:rs.3.rs-100914.|Viruses. 2021 Jun 28;13 (7) :1255.

• CAS Number :

  [84449-90-1]