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Raloxifene

CAT: 0804-HY-13738-01Size: 5 mgDry Ice: NoHazardous: No
HY-13738-015 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM) . Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[1].
CAS Number
[84449-90-1]
Product Name Alternative
Keoxifene; LY156758 (free base) ; LY139481
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/raloxifene.html
Purity
99.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4
Molecular Formula
C28H27NO4S
Molecular Weight
473.58
Precautions
H302, H312, H332
References & Citations
[1]Khovidhunkit W, et al. Clinical effects of raloxifene hydrochloride in women. Ann Intern Med. 1999;130 (5) :431-439.|[2]Xu H, et al. Effect of caffeine on ovariectomy-induced osteoporosis in rats. Biomed Pharmacother. 2019;112:108650.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Estrogen receptor
Citation 01
ACS Environ Au. 2025 Aug 8.|ACS Omega. 2023 Jun 14;8 (25) :22603-22612.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Biomed Pharmacother. 2025 Jan:182:117756.|bioRxiv. 2025 Sep 4.|Exp Mol Med. 2025 Sep;57 (9) :1978-1995.|J Pharm Biomed Anal. 2021 Feb 20:195:113870.|Mol Neurobiol. 2025 Mar;62 (3) :3934-3955.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Eberhard Karls Universität Tübingen. 2021 Aug.|Free Radic Biol Med. 2017 Jul:108:404-417.|Int Immunopharmacol. 2024 Nov 6;143 (Pt 3) :113542.|Med Sci Monit. 2019 Apr 29:25:3146-3153.|Oxid Med Cell Longev. 2021 Mar 20;2021:6699054.|PLoS Negl Trop Dis. 2019 Aug 20;13 (8) :e0007681. |Res Sq. 2020 Dec 31:rs.3.rs-100914.|Viruses. 2021 Jun 28;13 (7) :1255.

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