Beaucage reagent

• Description :

  Beaucage reagent is found to be potent in causing DNA cleavage[1][2][3].

• CAS Number :

  [66304-01-6]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Beaucage-reagent.html

• Purity :

  98.0

• Solubility :

  DMSO : ≥ 100 mg/mL|H2O : 0.14 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC=CC=C12)SS2(=O)=O

• Molecular Formula :

  C7H4O3S2

• Molecular Weight :

  200.24

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zheng J, et al. Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent. Org Biomol Chem. 2010 Mar 21;8 (6) :1293-5.|[2]C. F. H. Allen, et al. Working with Hazardous Chemicals. Organic Syntheses, Coll. Vol. 2, 1943, 580.|[3] Stec W J, et al. Bis (O, O-diisopropoxy phosphinothioyl) disulfide-a highly efficient sulfurizing reagent for cost-effective synthesis of oligo (nucleoside phosphorothioate) s[J]. Tetrahedron letters, 1993, 34 (33) : 5317-5320.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported