Golotimod

CAT: 0804-HY-14743-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14743-01Size:5 mg
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Description
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) [1][2][3].
CAS Number
[229305-39-9]
Product Name Alternative
SCV 07; Gamma-D-glutamyl-L-tryptophan
UNSPSC
12352209
Target
Bacterial; STAT
Type
Reference compound
Related Pathways
Anti-infection; JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/golotimod.html
Purity
98.04
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)
Smiles
O=C(CC[C@@](N)(C(O)=O)[H])N[C@]([H])(C(O)=O)CC1=CNC2=C1C=CC=C2
Molecular Formula
C16H19N3O5
Molecular Weight
333.34
References & Citations
[1]Rose WA 2nd, et al. An immunomodulating dipeptide, SCV-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) . Int J Antimicrob Agents. 2008 Sep;32 (3) :262-6.|[2]Geiger JL, et al. The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations. Oral Oncol. 2016 May;56:84-92.|[3]Watkins B, et al. Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07) . Oral Dis. 2010 Oct;16 (7) :655-60.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
STAT3

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