NV-5138

• Product Name Alternative:

  SC 0030

• UNSPSC Description:

  NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 is used for antidepressant studies[1][2].

• Target Antigen:

  mTOR

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nv-5138.html

• Purity:

  98.0

• Solubility:

  DMSO : 10 mg/mL (ultrasonic)

• Smiles:

  N[C@@H](CC(C)(C(F)F)C)C(O)=O

• Molecular Weight:

  181.182

• References & Citations:

  [1]Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9(1):4107.|[2]Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554.Cell Metab. 2024 Jun 18:S1550-4131(24)00189-X.|bioRxiv. 2023 Apr 24.|biorxiv. 2024 May 27.|McGill University. 2023 Jul 5.|Neuron. 2023 Oct 4;111(19):3028-3040.e6.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  Phase 2

• CAS Number:

  2095886-80-7