Urolithin A

CAT:
400-SIH-610-5MG
Size:
5 mg
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
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Urolithin A

  • Background:

    Urolithin A (UA) is a microbial metabolite of dietary ellagitannins produced in the gut (1). It has been shown to induce mitophagy and prolong lifespan in C. elegans and increase muscle function in rodents (2). It promotes mitophagy and suppresses NLRP3 inflammasome activation in LPS-induced BV2 microglial cells and in an MPTP-induced Parkinson’s disease model (3). The pro-mitophagy activity of Urolitin A may be beneficial in Alzheimer’s disease (4). Ex vivo UA-treated T cells display improved anti-tumor function (5).
  • Description:

    Mitophagy inducer
  • Product Name Alternative:

    3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; or 2',7-Dihydroxy-3,4-benzocoumarin
  • UNSPSC:

    41116105
  • Source:

    Synthetic
  • Purity:

    >98% (HPLC); NMR (Conforms)
  • Weight:

    0.005
  • Format:

    Pale-yellow powder
  • Solubility:

    May be dissolved in DMSO (50 mg/ml)
  • Molecular Formula:

    C13H8O4
  • Molecular Weight:

    228.2
  • Precautions:

    Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
  • References & Citations:

    1.Gonzalez-Barrio R., et al. (2011) J. Agric. Food. Chem. 59:1152 2.Ryu D., et al. 2016 Nat. Med. 22:879 3.Qiu J., et al. 2022 Neuropharmacology 207:108963 4.Jayatunga D.P.W., et al. 2021 Nutrients. 13:3744 5.Denk D., et al. 2022 Immunity. 55:2059
  • CAS Number:

    1143-70-0