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AS057278

CAT: 0804-HY-33009-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-33009-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 μM and EC50 of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP) -induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia[1].
CAS Number
402-61-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/as057278.html
Purity
99.76
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=NNC(C)=C1)O
Molecular Formula
C5H6N2O2
Molecular Weight
126.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Adage T, et al. In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties. Eur Neuropsychopharmacol. 2008;18 (3) :200-214.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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