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Lornoxicam-d4

CAT: 0804-HY-B0367S-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0367S-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lornoxicam-d4 is the deuterium labeled Lornoxicam. Lornoxicam (Chlortenoxicam), a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory agent (NSAID) .
CAS Number
1216527-48-8
Product Name Alternative
Chlortenoxicam-d4; Ro 13-9297-d4
UNSPSC
12352005
Hazard Statement
H301-H312-H330-H410
Target
COX; Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
OC(C1=C2C=C(S1)Cl)=C(C(NC3=C([2H])C([2H])=C([2H])C([2H])=N3)=O)N(C)S2(=O)=O
Molecular Formula
C13H6D4ClN3O4S2
Molecular Weight
375.84
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Spyra S, et al. COX-2-selective inhibitors celecoxib and deracoxib modulate transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2017 Aug;174 (16) :2696-2705.|[3]Rose, P. and C. Steinhauser, Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study) . Clin Drug Investig, 2004. 24 (4) : p. 227-36.|[4]Bianchi, M. and A.E. Panerai, Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. Pharmacol Res, 2002. 45 (2) : p. 101-5.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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