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RO5454948

CAT: 0804-HY-12838-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12838-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RO5454948 (Compound 9) is the inhibitor for Dyrk1B and Dyrk1A with IC50 of 68 nM and 22 nM. RO5454948 exhibits cytotoxicity in cancer cell SW620 with EC50 of 1.9 μM[1][2].
CAS Number
1386979-55-0
Product Name Alternative
Mirk-IN-1; Dyrk1B/A-IN-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ro5454948.html
Purity
99.53
Solubility
DMSO : 2 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
ClC1=CC=C(C(NCC2=CC(Cl)=CC=C2)=O)C=C1NC(C3=CC4=CN=C(OC)N=C4N=C3O)=O
Molecular Formula
C23H17Cl2N5O4
Molecular Weight
498.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Ewton DZ, et al. Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol Cancer Ther. 2011 Nov;10 (11) :2104-14.|[2]Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23 (24) :6610-5.|[3]Deng X, et al., Mirk kinase inhibition blocks the in vivo growth of pancreatic cancer cells. Genes Cancer. 2014 Sep;5 (9-10) :337-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1

Alternative Products

CatalogName
A16255-2RO5454948 (Mirk-IN-1) 2mg
A16255-50RO5454948 (Mirk-IN-1) 50mg
A16255-10RO5454948 (Mirk-IN-1) 10mg
A16255-5RO5454948 (Mirk-IN-1) 5mg
A16255-10mM-DRO5454948 (Mirk-IN-1) 10mM * 1mL in DMSO

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