NSC697923

• Description :

  NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H318

• Target :

  Apoptosis; E1/E2/E3 Enzyme

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nsc697923.html

• Concentration :

  10mM

• Purity :

  99.93

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  O=S(C1=CC=C([N+]([O-])=O)O1)(C2=CC=C(C)C=C2)=O

• Molecular Formula :

  C11H9NO5S

• Molecular Weight :

  267.26

• Precautions :

  H302, H318

• References & Citations :

  [1]Cheng J, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5 (2) :e1079. Published 2014 Feb 20.|[2]Hodge CD, et al. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. ACS Chem Biol. 2015;10 (7) :1718-1728.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [343351-67-7]