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NSC697923

CAT: 0804-HY-13811-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13811-01Size:5 mg
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Description
NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity[1][2].
CAS Number
343351-67-7
UNSPSC
12352005
Hazard Statement
H302, H318
Target
Apoptosis; E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc697923.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C([N+]([O-])=O)O1)(C2=CC=C(C)C=C2)=O
Molecular Formula
C11H9NO5S
Molecular Weight
267.26
Precautions
H302, H318
References & Citations
[1]Cheng J, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5 (2) :e1079. Published 2014 Feb 20.|[2]Hodge CD, et al. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. ACS Chem Biol. 2015;10 (7) :1718-1728.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
A8813-10NSC697923

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