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Dynapyrazole-A

CAT: 0804-HY-131873-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131873-06Size:100 mg
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Description
Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity[1].
CAS Number
2226517-75-3
UNSPSC
12352005
Target
Dynamin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dynapyrazole-a.html
Purity
98.17
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=C(N2)N(N=C1C3(C4=CC=C(Cl)C=C4)CC3)C5=C(C=C(I)C=C5)C2=O
Molecular Formula
C20H12ClIN4O
Molecular Weight
486.69
References & Citations
[1]Zhaoyang Jing, et al. Rotavirus Viroplasm Biogenesis Involves Microtubule-Based Dynein Transport Mediated by an Interaction between NSP2 and Dynein Intermediate Chain. J Virol. 2021 Oct 13;95 (21) :e0124621.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Dynapyrazole A
CAS Number2226517-75-3
PubChem CID136213044
IUPAC Name2-[1-(4-chlorophenyl)cyclopropyl]-7-iodo-5-oxo-4H-pyrazolo[1,5-a]quinazoline-3-carbonitrile
Molecular FormulaC20H12ClIN4O
Molecular Weight486.7
XLogP4.4
Topological Polar Surface Area70.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count27
Formal Charge0
Complexity668
SMILES
C1CC1(C2=CC=C(C=C2)Cl)C3=NN4C5=C(C=C(C=C5)I)C(=O)NC4=C3C#N
InChI
InChI=1S/C20H12ClIN4O/c21-12-3-1-11(2-4-12)20(7-8-20)17-15(10-23)18-24-19(27)14-9-13(22)5-6-16(14)26(18)25-17/h1-6,9H,7-8H2,(H,24,27)
InChIKey
VABPBCMFKJDOHP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dynapyrazole A
CAS: 2226517-75-3
CID: 136213044
Formula: C20H12ClIN4O
MW: 486.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight486.7
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass485.97444
Monoisotopic Mass485.97444
Topological Polar Surface Area70.7 Ų
Heavy Atom Count27
Formal Charge0
Complexity668
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA4570-100Dynapyrazole-A
6896/5Dynapyrazole A

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