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Arvenin I

CAT: 0804-HY-N6579-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6579-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Arvenin I is a natural cucurbitacin glucoside that activates T cells within the cancer-competitive environment. Arvenin I covalently reacts with and hyperactivates MKK3, thereby reviving the mitochondrial fitness of exhausted T cells through the activation of the p38MAPK pathway[1]. Arvenin I exhibits broad-spectrum antiproliferative against cancer cells[2]. Arvenin I enhances antitumor effects both as a monotherapy and in combination with immune checkpoint inhibitors in mice[1]. Arvenin I can be used for cancer research, such as colon cancer, breast cancer, lung cancer, and ovarian cancer[1][2].
CAS Number
65247-27-0
UNSPSC
12352005
Target
Mitochondrial Metabolism; p38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arvenin-i.html
Purity
89.41
Solubility
10 mM in DMSO
Smiles
CC(OC(C)(/C=C/C([C@@]([C@H]1[C@H](O)C[C@]2(C)[C@]1(C)CC([C@]3(C)[C@H]2CC=C4[C@H]3C[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)C(C4(C)C)=O)=O)(O)C)=O)C)=O
Molecular Formula
C38H56O13
Molecular Weight
720.84
References & Citations
[1]Takemoto M, et al. Covalent Plant Natural Product that Potentiates Antitumor Immunity. J Am Chem Soc. 2025 Jan 22;147 (3) :2902-2912.|[2]Minh CV, et al. Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities. Arch Pharm Res. 2015 Aug;38 (8) :1443-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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