Products for Research Use Only
RegisterLogin

Ethyl 3,4-dihydroxybenzoate

CAT: 0804-HY-W016409Size: 500 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-W016409Size:500 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema[1][2][3][4].
CAS Number
3943-89-3
Product Name Alternative
Protocatechuic acid ethyl ester
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Autophagy; HIF/HIF Prolyl-Hydroxylase; NO Synthase; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ethyl-3-4-dihydroxybenzoate.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC)C1=CC=C(O)C(O)=C1
Molecular Formula
C9H10O4
Molecular Weight
182.18
Precautions
H315, H319, H335
References & Citations
[1]Bo Han, et al. A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1. PLoS One. 2014 Sep 18;9 (9) :e107204.|[2]Sebastian Philipp, et al. Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS. Am J Physiol Heart Circ Physiol. 2006 Jan;290 (1) :H450-7.|[3]Byeong-Ju Kwon, et al. Ethyl-3,4-dihydroxybenzoate with a dual function of induction of osteogenic differentiation and inhibition of osteoclast differentiation for bone tissue engineering. Tissue Eng Part A. 2014 Nov;20 (21-22) :2975-84.|[4]Singh DP, et al. Ethyl 3,4-dihydroxybenzoate (EDHB) : a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain. J Physiol Sci. 2016 Jul;66 (4) :315-26.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-W131227-01Ethyl 3,5-dihydroxybenzoate
HY-Z0548-01Methyl 3,4-dihydroxybenzoate
HY-Z0548R-01Methyl 3,4-dihydroxybenzoate (Standard)
HY-Z0548S1-01Methyl 3,4-dihydroxybenzoate-d3-1
HY-W010076-01Methyl 2,4-dihydroxybenzoate
HY-34580Methyl 3,5-dihydroxybenzoate
HY-W001154-01Methyl 2,6-dihydroxybenzoate
HY-W012518-01Methyl 2,5-dihydroxybenzoate
HY-N8624Ethyl 3,4-dicaffeoylquinate
HY-41315-01Ethyl 3,3-dimethyl-4-nitrobutanoate

Alternative Products

CatalogName
TRC-E678500-100MGEthyl 3,4-Dihydroxybenzoate
TRC-E678502-1MGEthyl 3,4-Dihydroxybenzoate-13C3
E07620Ethyl 3,4-dihydroxybenzoate 97%
sc-234955Ethyl 2,4-dihydroxybenzoate
sc-234986Ethyl 3,5-dihydroxybenzoate
OR83436-01Ethyl 4-bromo-2,3-dihydroxybenzoate
sc-460083Ethyl 2,3-dihydroxybenzoate

Popular Products