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Leucosceptoside A

CAT: 0804-HY-N8018-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8018-01Size:1 mg
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Description
Leucosceptoside A is a phenylethanoid glycoside with anti-hyperglycemic and anti-hypertensive activities. Leucosceptoside A shows inhibitory activity against α-glucosidase and PKCα (IC50 of 19.0 μM) [1][2][3].
CAS Number
83529-62-8
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Glycosidase; PKC
Type
Natural Products
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; TGF-beta/Smad
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/leucosceptoside-a.html
Solubility
10 mM in DMSO
Smiles
COC(C=C1/C=C/C(O[C@H]([C@H](O[C@H]([C@@H]2O)OCCC3=CC(O)=C(C=C3)O)CO)[C@@H]2O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)=O)=C(C=C1)O
Molecular Formula
C30H38O15
Molecular Weight
638.61
References & Citations
[1]Chika Ifeanyi Chukwuma, et al. Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review. J Ethnopharmacol. 2019 May 10;235:329-360.|[2]Yan-Yun Li, et al. Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons. Eur J Pharmacol. 2008 Jan 28;579 (1-3) :134-40.|[3]B N Zhou, et al. Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61 (11) :1410-2.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PKCα

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CatalogName
AB1933Leucosceptoside A

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