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USL311

CAT: 0804-HY-114244-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-114244-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
USL311 is a potent and selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4[1].
CAS Number
1373268-67-7
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/USL311.html
Purity
99.97
Solubility
DMSO : 18.57 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(C1=NC(N2CCN(C3CCN(C(C)C)CC3)CCC2)=CC=C1)NC4=CC=NC=C4
Molecular Formula
C24H34N6O
Molecular Weight
422.57
Precautions
H315, H319, H320
References & Citations
[1]Peter Richardson. Usl-311 for use in the treatment of cancer. WO2018162924A1|[2]Takacs GP, et al. Modulation of the chemokine/chemokine receptor axis as a novel approach for glioma therapy. Pharmacol Ther. 2021 Jun;222:107790.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CXCR4

Chemical Information

Usl-311

USL-311 is under investigation in clinical trial NCT02765165 (Phase 1/2 Study of USL311 Alone and in Combination With Lomustine in Subjects With Advanced Solid Tumors and Relapsed/Recurrent Glioblastoma Multiforme (GBM)).

CAS Number1373268-67-7
PubChem CID56961879
IUPAC Name6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-N-pyridin-4-ylpyridine-2-carboxamide
Molecular FormulaC24H34N6O
Molecular Weight422.6
XLogP3
Topological Polar Surface Area64.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity558
SMILES
CC(C)N1CCC(CC1)N2CCCN(CC2)C3=CC=CC(=N3)C(=O)NC4=CC=NC=C4
InChI
InChI=1S/C24H34N6O/c1-19(2)28-15-9-21(10-16-28)29-13-4-14-30(18-17-29)23-6-3-5-22(27-23)24(31)26-20-7-11-25-12-8-20/h3,5-8,11-12,19,21H,4,9-10,13-18H2,1-2H3,(H,25,26,31)
InChIKey
XNUNVQKARNSSEO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Usl-311
CAS: 1373268-67-7
CID: 56961879
Formula: C24H34N6O
MW: 422.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight422.6
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass422.27940973
Monoisotopic Mass422.27940973
Topological Polar Surface Area64.6 Ų
Heavy Atom Count31
Formal Charge0
Complexity558
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA5300-1USL311
A18778-50USL311 50mg
A18778-5USL311 5mg
A18778-500USL311 500mg
A18778-25USL311 25mg
A18778-1USL311 1mg
A18778-100USL311 100mg
A18778-10USL311 10mg
A18778-10mM-DUSL311 10mM * 1mL in DMSO

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