ACE2 Rabbit pAb

ACE2 Rabbit pAb

• Description: Angiotensin I converting enzyme 2 (ACE2) Homo sapiens The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
• Synonyms: Angiotensin-converting enzyme 2 (EC 3.4.17.23) (ACE-related carboxypeptidase) (Angiotensin-converting enzyme homolog) (ACEH) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]
• Gene ID: 59272
• UniProt: Q9BYF1
• Cellular Locus: [Processed angiotensin-converting enzyme 2]: Secreted.; Cell membrane ; Single-pass type I membrane protein. Cytoplasm. Cell projection, cilium. Apical cell membrane. Detected in both cell membrane and cytoplasm in neurons..; [Isoform 2]: Apical cell membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthesized peptide derived from human ACE2 AA range: 425-475
• Clonality: Polyclonal
• Validated Applications: IHC, WB
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: IHC-p1:50-200,WB 1:1000-2000
• Molecular Weight: 120-135kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.