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KF38789

CAT: 0804-HY-103358-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103358-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM[1].
CAS Number
257292-29-8
UNSPSC
12352005
Target
P-selectin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/kf38789.html
Purity
99.63
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1OC(C)=CC(O)=C1C2=NCCSC(C2)C3=CC=C(C=C3OC)OC
Molecular Formula
C19H21NO5S
Molecular Weight
375.44
References & Citations
[1]S Ohta, et al. Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38789. Inflamm Res. 2001 Nov;50 (11) :544-51.|[2]Peter J Gillies, et al. Demonstration of P-selectin expression and potential function in human corneal epithelial cells. Exp Eye Res. 2018 Nov;176:196-206.|[3]Kay-Wee Poh, et al. Global gene expression analysis in the mouse brainstem after hyperalgesia induced by facial carrageenan injection--evidence for a form of neurovascular coupling? Pain. 2009 Mar;142 (1-2) :133-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
BUP01237-01KF38789

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