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PNU-120596

CAT: 0804-HY-12152-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12152-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PNU-120596 (NSC 216666) is a potent and selective α7 nAChR positive allosteric modulator (PMA) with an EC50 of 216 nM. PNU-120596 is inactive against α4β2, α3β4, and α9α10 nAChRs. PNU-120596 has the potential for psychiatric and neurological disorders research[1].
CAS Number
501925-31-1
Product Name Alternative
NSC 216666
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PNU-120596.html
Purity
99.49
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(Cl)=C(C=C1OC)OC)NC2=NOC(C)=C2
Molecular Formula
C13H14ClN3O4
Molecular Weight
311.72
Precautions
H302, H315, H320, H335
References & Citations
[1]Hurst RS, et al. A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J Neurosci, 2005, 25 (17), 4396-4405.|[2]Barron SC, et al. An allosteric modulator of alpha7 nicotinic receptors, N- (5-Chloro-2,4-dimethoxyphenyl) -N'- (5-methyl-3-isoxazolyl) -urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine. Mol Pharmacol, 2009 76 (2), 253-263.|[3]Munro G, et al. The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat. Br J Pharmacol, 2012, doi: 10.1111/j.1476-5381.2012.02003.x
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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