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RHC 80267

CAT: 0804-HY-107416-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107416-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC50 of 4 μM in canine platelets) . RHC-80267 inhibits cholinesterase activity with an IC50 of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC) [1][2][3][4].
CAS Number
83654-05-1
Product Name Alternative
U-57908
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Acyltransferase; COX; DAGL; mAChR; Phospholipase
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rhc-80267.html
Purity
99.41
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O/N=C1CCCCC\1)NCCCCCCNC(O/N=C2CCCCC/2)=O
Molecular Formula
C20H34N4O4
Molecular Weight
394.51
Precautions
H302, H315, H319, H335
References & Citations
[1] Sutherland CA, et al. Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267. J Biol Chem. 1982 Dec 10;257 (23) :14006-10.|[2]Ghisdal P, et al. The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action. Eur J Pharmacol. 2005 Jul 4;517 (1-2) :97-102.|[3]Karpińska O, et al. Activation of CB1 receptors by 2-arachidonoylglycerol attenuates vasoconstriction induced by U46619 and angiotensin II in human and rat pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2017 Jun 1;312 (6) :R883-R893.|[4]Oglesby TD, et al. The inhibition of arachidonic acid metabolism in human platelets by RHC 80267, a diacylglycerol lipase inhibitor. Biochim Biophys Acta. 1984 Apr 18;793 (2) :269-77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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