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NH2-GG-DSPE

CAT: 0804-HY-164579Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164579Size:1 Each
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Description
NH2-GG-DSPE is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.
CAS Number
1364335-16-9
UNSPSC
12352211
Target
Liposome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/nh2-gg-dspe.html
Smiles
NCC(NCC(NCCOP(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O
Molecular Formula
C45H88N3O10P
Molecular Weight
862.17
References & Citations
[1]Juliano R L, et al. Liposomes as a drug delivery system for antisense oligonucleotides[J]. Antisense research and development, 1992, 2 (2) : 165-176.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

[(2R)-3-[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]ethoxy-hydroxyphosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate
CAS Number1364335-16-9
PubChem CID146673319
IUPAC Name[(2R)-3-[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]ethoxy-hydroxyphosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate
Molecular FormulaC45H88N3O10P
Molecular Weight862.2
XLogP11.1
Topological Polar Surface Area193
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count11
Rotatable Bond Count47
Heavy Atom Count59
Formal Charge0
Complexity1070
SMILES
CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCNC(=O)CNC(=O)CN)OC(=O)CCCCCCCCCCCCCCCCC
InChI
InChI=1S/C45H88N3O10P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-44(51)55-39-41(40-57-59(53,54)56-36-35-47-43(50)38-48-42(49)37-46)58-45(52)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h41H,3-40,46H2,1-2H3,(H,47,50)(H,48,49)(H,53,54)/t41-/m1/s1
InChIKey
MGJCPUWDYOFYPO-VQJSHJPSSA-N
Chemical Structure
2D Structure
2D structure of [(2R)-3-[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]ethoxy-hydroxyphosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate
CAS: 1364335-16-9
CID: 146673319
Formula: C45H88N3O10P
MW: 862.2
Interactive 3D Structure
Loading 3D structure...
Computed Properties
PropertyValue
Molecular Weight862.2
XLogP311.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count11
Rotatable Bond Count47
Exact Mass861.62073301
Monoisotopic Mass861.62073301
Topological Polar Surface Area193 Ų
Heavy Atom Count59
Formal Charge0
Complexity1070
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes