Endothall

• Description :

  Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC50s of 90 nM and 5 µM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy[1].

• CAS Number :

  [145-73-3]

• Product Name Alternative :

  Endothal

• UNSPSC :

  12352005

• Hazard Statement :

  H300, H315, H319, H335

• Target :

  Phosphatase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/endothall.html

• Purity :

  96.6

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles :

  OC(C1C(C2CCC1O2)C(O)=O)=O

• Molecular Formula :

  C8H10O5

• Molecular Weight :

  186.16

• Precautions :

  H300, H315, H319, H335

• References & Citations :

  [1]Janetti R Signorelli, et al. Protein phosphatases decrease their activity during capacitation: a new requirement for this event. PLoS One. 2013 Dec 2;8 (12) :e81286.|[2]J P Thièry, et al. Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. Hepatology. 1999 May;29 (5) :1406-17.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported