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IFN-lambda 3/IL-28B, Mouse (HEK293, His)

CAT: 0804-HY-P74851Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P74851Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IFN-lambda 3 (IL-28B) is a member of the Type-III interferon family. IFN-lambda 3 has high similar 96% sequence identity with IFN-lambda 2 at the amino acid level. IFN-lambda 2 has antiviral antitumour and immunomodulatory activities[1]. IFN-lambda 2 signals through a heterodimeric receptor complex comprising IFNLR1 and IL-10RB. When binding to the receptor complex, Jak1 and Tyk2 will be activated, and leads to tyrosine phosphorylation of the IFN-λR1 and activation of STAT1 and STAT2. Activated STAT1 and STAT2 together with IRF-9 form a trimeric transcription factor complex (ISGF3) . The formed ISGF3 then translocate to the nucleus and promotes the production of IFN-stimulated genes (ISGs) [2]. IFN-lambda 3/IL-28B Protein, Mouse (HEK293, His) is a recombinant mouse IFN-lambda 3 (D20-V193) with C-terminal His tag, which is expressed in HEK293.
Product Name Alternative
IFN-lambda 3/IL-28B Protein, Mouse (HEK293, His), Mouse, HEK293
UNSPSC
12352202
Type
Recombinant Proteins
Assay Protocol
https://www.medchemexpress.com/cytokines/ifn-lambda-3-il-28b-protein-mouse-hek293-his.html
Purity
98.0
Molecular Formula
338374 (Gene_ID) Q8CGK6 (D20-V193) (Accession)
Molecular Weight
Approximately 27.52 kDa and 23.53 kDa
References & Citations
[1]Lopušná K, et al. Interferons lambda, new cytokines with antiviral activity. Acta Virol. 2013;57 (2) :171-9.|[2]Donnelly RP, et al. Interferon-lambda: a new addition to an old family. J Interferon Cytokine Res. 2010 Aug;30 (8) :555-64.|[3]Witte K, et al. IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties. Cytokine Growth Factor Rev. 2010 Aug;21 (4) :237-51. |[4]Metwally M, et al. IFNL3 genotype is associated with pulmonary fibrosis in patients with systemic sclerosis. Sci Rep. 2019 Oct 16;9 (1) :14834.|[5]Yoshimoto K, et al. Interleukin-28B acts synergistically with cisplatin to suppress the growth of head and neck squamous cell carcinoma. J Immunother. 2011 Mar;34 (2) :139-48.
Shipping Conditions
Room temperature in continental US; may vary elsewhere.
Storage Conditions
Stored at -20°C for 2 years
Scientific Category
Recombinant Proteins

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