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Pradefovir

CAT: 0804-HY-112690Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-112690Size:1 Each
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Description
Pradefovir is a good substrate for liver CYP3A4. Pradefovir is converted to 9- (2-phosphonylmethoxyethyl) adenine (PMEA) in human liver microsomes with a Km of 60 μM.
CAS Number
625095-60-5
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pradefovir.html
Solubility
10 mM in DMSO
Smiles
NC1=C2N=CN(CCOC[P@]3(OCC[C@@H](C4=CC=CC(Cl)=C4)O3)=O)C2=NC=N1
Molecular Formula
C17H19ClN5O4P
Molecular Weight
423.79
References & Citations
[1]Lin CC, et al. Metabolic activation of Pradefovir by CYP3A4 and its potential as an inhibitor or inducer. Antimicrob Agents Chemother. 2006 Sep;50 (9) :2926-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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