3,4-Dicaffeoylquinic acid

3,4-Dicaffeoylquinic acid

• CAS Number: 14534-61-3
• UNSPSC Description: 3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL[1][2][3].
• Target Antigen: Apoptosis; Endogenous Metabolite; Glycosidase; Influenza Virus
• Type: Natural Products
• Related Pathways: Anti-infection;Apoptosis;Metabolic Enzyme/Protease
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/3,4-Dicaffeoylquinic-acid.html
• Purity: 98.64
• Solubility: DMSO : 50 mg/mL (ultrasonic)|Methanol : 83.33 mg/mL (ultrasonic)
• Smiles: O=C([C@@]1(O)C[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[C@H](OC(/C=C/C3=CC=C(O)C(O)=C3)=O)[C@H](O)C1)O
• Molecular Weight: 516.45
• References & Citations: [1]Takemura T, et al. 3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus. Evid Based Complement Alternat Med. 2012;2012:946867.|[2]Liu X, et al. Protective effect of isochlorogenic acid B on liver fibrosis in non-alcoholic steatohepatitis of mice. Basic Clin Pharmacol Toxicol. 2019;124(2):144-153.|[3]Ooi KL, et al. Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth. J Ethnopharmacol. 2011;135(3):685-695.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported