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NFh-ALP

CAT: 0804-HY-159485Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159485Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NFh-ALP is an alkaline phosphatase (ALP) -activatable photosensitizer. NFh-ALP could be activated by ALP in cells and generate 1O2 under 808 nm excitation, effectively killing tumor cells by inducing apoptosis and having good biocompatibility. The maximum absorption wavelength of NFh-ALP is about 656 nm[1].
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nfh-alp.html
Smiles
CC1(C)C(/C=C/C(CCC2)=C3C2=CC(C=C(Br)C(OP(O)(O)=O)=C4)=C4O3)=[N+](CC)C5=CC=C(Br)C=C15.[I-]
Molecular Formula
C27H27Br2INO5P
Molecular Weight
763.19
References & Citations
[1]Chao Zhao, et al. Alkaline Phosphatase Activated Near-Infrared Frequency Upconversion Photosensitizers for Tumor Photodynamic Therapy. J Med Chem. 2024 Aug 8;67 (15) :13383-13391.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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