α-Casozepine

• Description :

  α-Casozepine is a bioactive peptide derived from the α protein S1 casein in milk and has an affinity for γ-aminobutyric acid (GABA) receptors in the brain. α-Casozepine has anti-anxiety effects[1][2].

• UNSPSC :

  12352209

• Target :

  GABA Receptor

• Type :

  Peptides

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/α-casozepine.html

• Purity :

  99.36

• Solubility :

  DMSO : 20 mg/mL (ultrasonic; warming) |H2O : 66.67 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl)

• Smiles :

  OC(C=C1)=CC=C1C[C@H](NC(CNC([C@H](CC(C)C)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C60H94N14O16

• Molecular Weight :

  1267.47

• References & Citations :

  [1]Miclo L, et al. Characterization of alpha-casozepine, a tryptic peptide from bovine alpha (s1) -casein with benzodiazepine-like activity. FASEB J. 2001 Aug;15 (10) :1780-2.|[2]Landsberg G, et al Therapeutic effects of an alpha-casozepine and L-tryptophan supplemented diet on fear and anxiety in the cat. J Feline Med Surg. 2017 Jun;19 (6) :594-602.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [117592-45-7]