Obtustatin

• Description:

  Obtustatin is a non-RGD disintegrin of 41 residues. Obtustatin can be isolated from Vipera lebetina obtusa venom. Obtustatin is a potent and selective inhibitor of the adhesion of integrin α1β1 to collagen IV. Obtustatin inhibits angiogenesis, and can be used for research of cancer[1][2].

• UNSPSC:

  12352209

• Target:

  Integrin

• Type:

  Peptides

• Related Pathways:

  Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/obtustatin.html

• Purity:

  99.69

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C ([C@@H] (N) CSSC[C@H] (NC1=O) C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N2[C@H] (C (N[C@H] (C (NCC (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H]3CC4=CC=C (O) C=C4) =O) CC5=CNC=N5) =O) CO) =O) [C@@H] (C) O) =O) CC (C) C) =O) CO) =O) [C@@H] (C) O) =O) CCCCN) =O) CC6=CNC7=CC=CC=C67) =O) CSSC[C@H] (NC8=O) C (N9[C@H] (C (N[C@H] (C (N[C@H] (C (N%10[C@H] (C (NCC (O) =O) =O) CCC%10) =O) CC%11=CC=C (O) C=C%11) =O) CC (C) C) =O) CCC9) =O) =O) [C@@H] (C) O) =O) [C@@H] (C) O) =O) =O) C) =O) CCC2) =O) CCCCN) =O) CC (C) C) =O) CCCCN) =O) N[C@H] (C (N[C@H] (C (NCC (N%12[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H]1CCC (N) =O) =O) CCCNC (N) =N) =O) CSSC[C@H] (NC%13=O) C (N[C@H]8CC (O) =O) =O) =O) CSSC[C@H] (NC3=O) C (N[C@H] (C (NCC (NC (C (NC%13CO) =O) CCCCN) =O) =O) [C@@H] (C) O) =O) =O) CCC%12) =O) =O) [C@@H] (C) O) =O) [C@@H] (C) O

• Molecular Formula:

  C184H284N52O57S8

• Molecular Weight:

  4393.06

• References & Citations:

  [1]Paz Moreno-Murciano M, et al. NMR solution structure of the non-RGD disintegrin obtustatin. J Mol Biol. 2003 May 23;329 (1) :135-45.|[2]Marcinkiewicz C, et al. Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo. Cancer Res. 2003 May 1;63 (9) :2020-3.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  404882-00-4