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Auriculasin

CAT: 0804-HY-N2911Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2911Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Auriculasin is an anticancer agent that inhibits VEGFR2, PI3K/AKT/mTOR, MAPK. Auriculasin can inhibit cell proliferation, induce cell apoptosis, and inhibit angiogenesis, and promotes mitochondrial oxidative stress and ferroptosis. Auriculasin is also active at the cannabinoid receptor CB1 with an IC50 of 8.92 μM. Auriculasin can be used in cancer research, especially related diseases such as prostate cancer and non-small cell lung cancer, as well as research on the development of anti-angiogenic drugs[1][2][3][4][5].
CAS Number
60297-37-2
UNSPSC
12352005
Target
Akt; Cannabinoid Receptor; Ferroptosis; mTOR; p38 MAPK; PI3K; VEGFR
Type
Natural Products
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/auriculasin.html
Purity
99.1
Solubility
10 mM in DMSO
Smiles
O=C1C(C(O)=C(C=CC(C)(C)O2)C2=C3C/C=C(C)\C)=C3OC=C1C4=CC=C(O)C(O)=C4
Molecular Formula
C25H24O6
Molecular Weight
420.45
References & Citations
[1]Cho HD, et al. Effects of auriculasin on vascular endothelial growth factor (VEGF) -induced angiogenesis via regulation of VEGF receptor 2 signaling pathways in vitro and in vivo. Food Chem Toxicol. 2018 Nov;121:612-621.|[2]Cho HD, et al. Auriculasin sensitizes primary prostate cancer cells to TRAIL-mediated apoptosis through up-regulation of the DR5-dependent pathway. Food Chem Toxicol. 2019 Apr;126:223-232.|[3]Cho HD, et al. Auriculasin-induced ROS causes prostate cancer cell death via induction of apoptosis. Food Chem Toxicol. 2018 Jan;111:660-669.|[4]Wang X, et al. Auriculasin induces mitochondrial oxidative stress and drives ferroptosis by inhibiting PI3K/Akt pathway in non-small cell lung cancer. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan;398 (1) :967-977.|[5]Dizamatova A, et al. A New Prenylated Isoflavonoid From Limonium leptophyllum. Natural Product Communications. May 2019.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CB1; VEGFR2/KDR/Flk-1

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