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CHDI-00484077

CAT: 0804-HY-148624-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148624-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHDI-00484077 (Compound 12) is a CNS-penetrant class IIa HDAC inhibitor, with IC50s of 0.01 μM (HDAC4), 0.02 μM (HDAC5), 0.02 μM (HDAC7), 0.03 μM (HDAC9) respectively. CHDI-00484077 can be used for research of huntington’s disease[1].
CAS Number
3025894-92-9
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chdi-00484077.html
Smiles
FC(F)(C1=NC(C2=CC=C(C=C2)C(N[C@H](C)CN3[C@H](CCC3)C)=O)=NO1)F
Molecular Formula
C18H21F3N4O2
Molecular Weight
382.38
References & Citations
[1]Stott AJ, et al. Evaluation of 5- (Trifluoromethyl) -1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease. ACS Med Chem Lett. 2021 Feb 11;12 (3) :380-388.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9

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