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Romazarit

CAT: 0804-HY-106027Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106027Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Romazarit (RO 31-3948) is an anti-inflammatory agent with antirheumatic effect. Romazarit exhibits PPARα agonist activity. Romazarit (30 mg/kg) inhibits the development of hindpaw inflammation in an adjuvant arthritis model[1][2][3].
CAS Number
109543-76-2
Product Name Alternative
RO 31-3948
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/romazarit.html
Smiles
CC(C)(OCC1=C(C)N=C(C2=CC=C(Cl)C=C2)O1)C(O)=O
Molecular Formula
C15H16ClNO4
Molecular Weight
309.74
References & Citations
[1]Bloxham DP, et al. Biologic properties of romazarit (Ro 31-3948), a potential disease-modifying antirheumatic drug. J Pharmacol Exp Ther. 1990 Mar;252 (3) :1331-40.|[2]Pillai AD, et al. Tetra substituted thiophenes as anti-inflammatory agents: exploitation of analogue-based drug design. Bioorg Med Chem. 2005 Dec 15;13 (24) :6685-92. |[3]Clary Clish, et al. Romazarit for treating metabolic diseases. WO2010014771A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα

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CatalogName
T26118-01Romazarit

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