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Thiocolchicine

CAT: 0804-HY-116852-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116852-01Size:5 mg
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Description
Thiocolchicine, a derivative modified in the C Ring of Colchicine with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 μM) and competitively binds to tubulin with a Ki of 0.7 μM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.
CAS Number
2730-71-4
Product Name Alternative
(±)-4-Hydroxy Propranolol-d16, (±)-4-Hydroxy Propranolol-d7 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H300+H330-H318-H340
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thiocolchicine.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(SC)C2=O)=O
Molecular Formula
C22H25NO5S
Molecular Weight
415.50
Precautions
P260-P264-P270-P271-P280-P284-P304+P340-P305+P351+P338-P330-P403+P233-P405-P501
References & Citations
[1]Klaus M.Hahn, et al. Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent. Bioorganic & Medicinal Chemistry Letters.Volume 1, Issue 9, 1991, Pages 471-476|[2]R De Vincenzo, et al. Antiproliferative Activity of Colchicine Analogues on MDR-positive and MDR-negative Human Cancer Cell Lines. Anticancer Drug Des. 1998 Jan;13 (1) :19-33.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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