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BT173

CAT: 0804-HY-128439-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128439-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BT173 is a potent homeodomain interacting protein kinase 2 (HIPK2) inhibitor. BT173 binds to HIPK2 and does not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. BT173 attenuates renal fibrosis through suppression of the TGF-β1/Smad3 pathway. BT173 can be studied in research for kidney diseases such as renal fibrosis[1].
CAS Number
2232180-74-2
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bt173.html
Purity
98.71
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=CC=C2C=C(C3=NC(C4=CC=C(Br)C=C4)=NO3)C=NC2=C1
Molecular Formula
C18H12BrN3O2
Molecular Weight
382.21
Precautions
H315, H319, H320
References & Citations
[1]Ruijie Liu, et al. A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF- β 1/Smad3 Pathway. J Am Soc Nephrol. 2017 Jul;28 (7) :2133-2143.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
M28979-01BT173

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