Products for Research Use Only
RegisterLogin

Rubitecan

CAT: 0804-HY-13744-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13744-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells[1][2][3].
CAS Number
91421-42-0
Product Name Alternative
RFS 2000; 9-Nitrocamptothecin
UNSPSC
12352005
Hazard Statement
H301
Target
Topoisomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rubitecan.html
Concentration
10mM
Purity
99.23
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C([N+]([O-])=O)C=CC=C5N=C4C3=C2)=O
Molecular Formula
C20H15N3O6
Molecular Weight
393.35
Precautions
H301
References & Citations
[1]Burris HA 3rd, et al. Phase II trial of oral rubitecan in previously treated pancreatic cancer patients. Oncologist. 2005 Mar;10 (3) :183-90.|[2]Rubitecan: 9-NC, 9-Nitro-20 (S) -camptothecin, 9-nitro-camptothecin, 9-nitrocamptothecin, RFS 2000, RFS2000. Drugs R D. 2004;5 (5) :305-11.|[3]Rubitecan|[4]Xia M, et al. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 2013 Jul;14 (7) :638-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 3

Alternative Products

CatalogName
TBZ2667Rubitecan
A22040-50Rubitecan 50mg
A22040-25Rubitecan 25mg
A22040-5Rubitecan 5mg
A22040-100Rubitecan 100mg
A22040-10Rubitecan 10mg
A22040-10mM-DRubitecan 10mM * 1mL in DMSO

Popular Products