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RWJ52353

CAT: 0804-HY-103216Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-103216Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RWJ52353 is a selective, orally active ligand for α2D adrenoceptor, which binds α2D, α2A, α2B and α1 receptors, with Kis of 1.5, 254, 621 and 443 nM. RWJ52353 exhibits analgesic efficacy in mouse abdominal irritation test (MAIT), with an ED50 of 15.1 mg/kg[1].
CAS Number
245744-10-9
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rwj52353.html
Smiles
C1(C2=CCCC3=C2C=CS3)=CN=CN1
Molecular Formula
C11H10N2S
Molecular Weight
202.28
References & Citations
[1]Ross TM, et al., alpha (2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4- (4-Imidazo) -1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha (2D) adrenergic receptor. J Med Chem. 2000 Mar 9;43 (5) :765-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor

Alternative Products

CatalogName
T87348-01RWJ52353 hydrochloride

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