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306Oi10

CAT: 0804-HY-151507-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-151507-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery[1][2].
CAS Number
2322290-93-5
UNSPSC
12352211
Hazard Statement
H225, H319
Target
Liposome
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/306oi10.html
Purity
98.07
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(CCN(CCCN(CCCN(CCC(OCCCCCCCC(C)C)=O)CCC(OCCCCCCCC(C)C)=O)C)CCC(OCCCCCCCC(C)C)=O)OCCCCCCCC(C)C
Molecular Formula
C59H115N3O8
Molecular Weight
994.56
Precautions
H225, H319
References & Citations
[1]Hajj K A. Lipid Nanoparticle Systems for the Delivery of Messenger RNA. Carnegie Mellon University, 2019.|[2]Hajj KA, et al. Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH. Small. 2019 Feb;15 (6) :e1805097. doi: 10.1002/smll.201805097.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

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