Products for Research Use Only
RegisterLogin

UCM05

CAT: 0804-HY-110354-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-110354-02Size:10 mM - 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli.
CAS Number
1094451-90-7
Product Name Alternative
G28UCM
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Antibiotic; Bacterial; Fatty Acid Synthase (FASN)
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/ucm05.html
Purity
99.22
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC1=CC(OC(C2=CC(O)=C(C(O)=C2)O)=O)=CC3=CC=CC=C31)C4=CC(O)=C(C(O)=C4)O
Molecular Formula
C24H16O10
Molecular Weight
464.38
Precautions
H302, H315, H319
References & Citations
[1]Teresa Puig, et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 2011;13 (6) :R131.|[2]Swayansiddha Tripathy, et al. FtsZ inhibitors as a new genera of antibacterial agents. Bioorg Chem. 2019 Oct;91:103169.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1,3-Bis((3,4,5-trihydroxybenzoyl)oxy)naphthalene
CAS Number1094451-90-7
PubChem CID24896615
IUPAC Name[4-(3,4,5-trihydroxybenzoyl)oxynaphthalen-2-yl] 3,4,5-trihydroxybenzoate
Molecular FormulaC24H16O10
Molecular Weight464.4
XLogP3.9
Topological Polar Surface Area174
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity707
SMILES
C1=CC=C2C(=C1)C=C(C=C2OC(=O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
InChI
InChI=1S/C24H16O10/c25-16-6-12(7-17(26)21(16)29)23(31)33-14-5-11-3-1-2-4-15(11)20(10-14)34-24(32)13-8-18(27)22(30)19(28)9-13/h1-10,25-30H
InChIKey
KJCWIWDPTNVWRX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,3-Bis((3,4,5-trihydroxybenzoyl)oxy)naphthalene
CAS: 1094451-90-7
CID: 24896615
Formula: C24H16O10
MW: 464.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight464.4
XLogP33.9
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Exact Mass464.07434670
Monoisotopic Mass464.07434670
Topological Polar Surface Area174 Ų
Heavy Atom Count34
Formal Charge0
Complexity707
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19201608-01UCM05

Popular Products