Tideglusib

• Description :

  Tideglusib (NP031112) is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.

• CAS Number :

  [865854-05-3]

• Product Name Alternative :

  NP031112

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  GSK-3

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Tideglusib.html

• Concentration :

  10mM

• Purity :

  99.76

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles :

  O=C(N(SC1=O)C2=C3C=CC=CC3=CC=C2)N1CC4=CC=CC=C4

• Molecular Formula :

  C19H14N2O2S

• Molecular Weight :

  334.39

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Domínguez JM, et al. Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib. J Biol Chem, 2012, 287 (2), 893-90|[2]Luna-Medina R, et al. NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. J Neurosci, 2007, 27 (21), 5766-5776.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  GSK-3β