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Tideglusib

CAT: 0804-HY-14872-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14872-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tideglusib (NP031112) is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.
CAS Number
865854-05-3
Product Name Alternative
NP031112
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tideglusib.html
Concentration
10mM
Purity
99.76
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(N(SC1=O)C2=C3C=CC=CC3=CC=C2)N1CC4=CC=CC=C4
Molecular Formula
C19H14N2O2S
Molecular Weight
334.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Domínguez JM, et al. Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib. J Biol Chem, 2012, 287 (2), 893-90|[2]Luna-Medina R, et al. NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. J Neurosci, 2007, 27 (21), 5766-5776.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
GSK-3β

Alternative Products

CatalogName
T3067-01Tideglusib

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