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T5342126

CAT: 0804-HY-123789-01Size: 1 mg (21.83 mM x 100 μL in Methyl Acetate)Dry Ice: NoHazardous: No
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CAT#:0804-HY-123789-01Size:1 mg (21.83 mM x 100 μL in Methyl Acetate)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s=110.5, 315.6, and 318.4 μM, respectively) . T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
CAS Number
956507-49-6
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/t5342126.html
Concentration
21.83 mM * 1 mL in Methyl acetate
Purity
98.1
Smiles
OC(COC1=CC=C(OCC)C=C1)CN(CC2=C(C)N(CC3=CC=CC=C3Cl)N=C2C)C
Molecular Formula
C25H32ClN3O3
Molecular Weight
457.99
References & Citations
[1]Chavez, et al. Development of β-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antiseptics. J. Med. Chem. 54 (13), 4659-4669 (2011) .
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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