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Chloramphenicol succinate

CAT: 0804-HY-N7114Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N7114Size:1 Each
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Description
Chloramphenicol succinate is a proagent of Chloramphenicol, with Haemotoxicity. Chloramphenicol succinate also is an antibiotic. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity[1][2][3][4].
CAS Number
3544-94-3
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/chloramphenicol-succinate.html
Solubility
10 mM in DMSO
Smiles
O=C(OC[C@@H](NC(C(Cl)Cl)=O)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)CCC(O)=O
Molecular Formula
C15H16Cl2N2O8
Molecular Weight
423.20
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Ambrose PJ. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clin Pharmacokinet. 1984 May-Jun;9 (3) :222-38.|[2]Ambekar CS, et al. Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity. Toxicol In Vitro. 2004 Aug;18 (4) :441-7.|[3]Turton JA, et al. Haemotoxicity of chloramphenicol succinate in the CD-1 mouse and Wistar Hanover rat. Hum Exp Toxicol. 1999 Sep;18 (9) :566-76.|[4]Lofrano G, et al. Photocatalytic degradation of the antibiotic chloramphenicol and effluent toxicity effects. Ecotoxicol Environ Saf. 2016 Jan;123:65-71.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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