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TMS

CAT: 0804-HY-19340-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19340-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TMS ((E) -2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC50 of 6 nM and a Ki value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC50=300 nM) and CYP1A2 (IC50=3.1 μM) . TMS is a methylated derivative of resveratrol and has anti-cancer activity[1][2][3].
CAS Number
24144-92-1
Product Name Alternative
(E) -2,3',4,5'-tetramethoxystilbene
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TMS.html
Purity
99.40
Solubility
DMSO : ≥ 50 mg/mL
Smiles
COC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C(OC)=C1
Molecular Formula
C18H20O4
Molecular Weight
300.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Einem Lindeman T, et al. The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene. Mutagenesis. 2011 Sep;26 (5) :629-35.|[2]Jennings BL, et al. Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats. Cardiovasc Drugs Ther. 2014 Apr;28 (2) :145-61.|[3]Sanghee Kim, et al. Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem. 2002 Jan 3;45 (1) :160-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1

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