Products for Research Use Only
RegisterLogin

Zederone

CAT: 0804-HY-N1050-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N1050-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with IC50s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD50 value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin -resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis[1][2][3][4][5][6].
CAS Number
7727-79-9
UNSPSC
12352005
Target
Bacterial; mTOR; Ribosomal S6 Kinase (RSK)
Type
Natural Products
Related Pathways
Anti-infection; MAPK/ERK Pathway; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zederone.html
Purity
99.61
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC1=COC(C/C(C)=C/CC[C@]2(C)[C@@]3([H])O2)=C1C3=O
Molecular Formula
C15H18O3
Molecular Weight
246.30
References & Citations
[1]Prapapan Pimkaew, et al. Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice. Int J Toxicol. 2013 Nov-Dec;32 (6) :454-62.|[2]Zhilei Zhang, et al. A study of zederone for the inhibition on ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. J BUON. 2020 Mar-Apr;25 (2) :785-791.|[3]Pimkaew P, et al. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. Toxicol In Vitro. 2013 Sep;27 (6) :2005-12.|[4]Kader M G, et al. Zederone from the rhizomes of Zingiber zerumbet and its anti-staphylococcal activity[J]. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 2010, 9 (1) : 63-68.|[5]Anuchapreeda S, et al. Characterization and biological properties of zederone and zedoarondiol from rhizomes of En-lueang (Curcuma cf. Amada) [J]. Natural Product Communications, 2018, 13 (12) .|[6]Borah S, Sarkar P, Sharma HK. Zederone Improves the Fecal Microbial Profile in Dementia Induced Rat Model: A First Report. CNS Neurol Disord Drug Targets. 2022;21 (4) :335-342.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MTOR

Alternative Products

CatalogName
BA8715-5Zederone

Popular Products