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Borrelidin

CAT: 0804-HY-N6742-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6742-01Size:500 µg
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Description
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei[1]. Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 μM[2]. Borrelidin is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells[3]. Borrelidin has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively[4].
CAS Number
7184-60-3
Product Name Alternative
Treponemycin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Apoptosis; CDK; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/borrelidin.html
Purity
99.80
Solubility
Ethanol : ≥ 100 mg/mL
Smiles
O=C([C@H]1[C@H]([C@H](C/C=C/C=C(C#N)\[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)C2)OC2=O)CCC1)O
Molecular Formula
C28H43NO6
Molecular Weight
489.64
Precautions
H302, H315, H319, H335
References & Citations
[1]Habibi D, et al. Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia. Invest New Drugs. 2012 Aug;30 (4) :1361-70.|[2]Tsuchiya E, et al. Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae. J Antibiot (Tokyo) . 2001 Jan;54 (1) :84-90.|[3]Wakabayashi T, et al. Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. J Antibiot (Tokyo) . 1997 Aug;50 (8) :671-6.|[4]Otoguro K, et al. In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia. J Antibiot (Tokyo) . 2003 Aug;56 (8) :727-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Macrolide; Plasmodium

Alternative Products

CatalogName
254805Borrelidin
207093-01Borrelidin (Treponemycin, U 78548, C2989)
MBS651415-01Borrelidin (Treponemycin, Antibiotic U 78548, Antibiotic C2989)
TBI1399-1MGBorrelidin, Threonyl-tRNA synthase inhibitor; Angiogenesis inhibitor

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