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Feprazone

CAT: 0804-HY-114911-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114911-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Feprazone (DA2370; Prenazone), an analogue of Phenylbutazone , is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic activities. Feprazone acts by inhibiting the activity of cyclooxygenase (COX) -2. Feprazone ameliorates free fatty acid (FFA) -induced oxidative stress by reducing the production of mitochondrial reactive oxygen species (ROS). Feprazone can decrease the expression of MMP-2 and MMP-9. Besides, Feprazone can suppress adipogenesis and increase lipolysis in differentiating 3 T3-L1 cells. Feprazone also can be used to research atherosclerosis and obesity[1][2][3].
CAS Number
30748-29-9
Product Name Alternative
DA2370; Prenazone; Zepelin
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
COX; MMP; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/feprazone.html
Purity
99.88
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3)C1C/C=C(C)\C
Molecular Formula
C20H20N2O2
Molecular Weight
320.39
Precautions
H315, H319, H335
References & Citations
[1]Song M, et al. Feprazone Prevents Free Fatty Acid (FFA) -Induced Endothelial Inflammation by Mitigating the Activation of the TLR4/MyD88/NF-κB Pathway. ACS Omega. 2021 Feb 9;6 (7) :4850-4856.|[2]Fletcher MR, et al. Feprazone, a new anti-inflammatory agent. Studies of potency and gastrointestinal tolerance. Ann Rheum Dis. 1975 Apr;34 (2) :190-4.|[3]Che L, et al. Feprazone Displays Antiadipogenesis and Antiobesity Capacities in in Vitro 3 T3-L1 Cells and in Vivo Mice. ACS Omega. 2021 Mar 7;6 (10) :6674-6680.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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